Quick answer to how long does it take to cook a two pound meatloaf: 1 hour and 30 minutes.
The size and shape of the pan will affect how long it takes to cook a two pound meatloaf. The cooking time in an oven heated to 350 degrees Fahrenheit is 1 hour and 20 minutes to 1 hour and 40 minutes. Using a meat thermometer, the ground beef will be completely cooked and safe to eat when the meatloaf has an internal temperature of 160 degrees.